increased when they are used

This change in therapeutic approach is the result of several research findings: 1) joint damage starts early; 2) ARMEs provide significant benefits when administered early; 3) the benefits of the ARMEs can be increased when they are used in combination) new EMRAs have appeared with sufficient evidence of beneficial effects.

Patients with mild disease and normal radiographs may begin treatment with hydroxychloroquine, sulfasalazine, or minocycline, although, the authors note, methotrexate is also an option https://foodsocietyx.com/keto-viante. Patients with more severe disease or radiographic signs should start treatment with methotrexate.